autologous anti-CD19 chimeric antigen receptor T cells C-CAR011

{
  "id": "MLC-T-ONC-011372",
  "term": "autologous anti-CD19 chimeric antigen receptor T cells C-CAR011",
  "field": "Oncology and biomedicine",
  "definition": "A proprietary preparation of autologous T lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a second-generation chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD19 CAR T cells C-CAR011 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous anti-CD19 CAR-T cells C-CAR011",
    "autologous CD19-specific CAR-T cells C-CAR011",
    "autologous anti-CD19 CART cells C-CAR011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-chimeric-antigen-receptor-t-cells-c-car011/"
}