autologous anti-CD19 CAR-T cells TBI-1501

{
  "id": "MLC-T-ONC-011371",
  "term": "autologous anti-CD19 CAR-T cells TBI-1501",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes that have been transduced, via a proprietary technology involving a recombinant human fibronectin fragment to enhance transduction efficiency, with a retroviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, anti-CD19-CAR-expressing autologous T lymphocytes TBI-1501 target and bind to CD19-expressing neoplastic B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of the costimulatory signaling domains increase proliferation and activation of T cells.",
  "synonyms": [
    "CAR19 T lymphocytes TBI-1501",
    "anti-CD19-CAR T cells TBI-1501",
    "autologous anti-CD19 chimeric antigen receptor T cells TBI-1501"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-t-cells-tbi-1501/"
}