autologous CD19-targeted CAR-T cells GC007F

{
  "id": "MLC-T-ONC-011546",
  "term": "autologous CD19-targeted CAR-T cells GC007F",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19 coupled to as of yet not fully elucidated co-stimulatory molecules, with potential immunostimulating and antineoplastic activities. Upon transfusion, autologous CD19-targeted CAR-T cells GC007F target and bind to CD19-expressing neoplastic B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis. CD19, cluster of differentiation 19, is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. The processing platform used, FasT (F) CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours.",
  "synonyms": [
    "FasTCAR-19",
    "autologous CAR-T cells GC007F",
    "autologous anti-CD19-CAR-T cells GC007F",
    "GC007F CAR-T cells",
    "FasT CAR-19",
    "CD19 FasT CAR-T cells GC007F"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd19-targeted-car-t-cells-gc007f/"
}