CD19-targeted CAR T cells BZ019

{
  "id": "MLC-T-ONC-012382",
  "term": "CD19-targeted CAR T cells BZ019",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified and transduced with a non-viral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-targeted CAR T cells BZ019 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "anti-CD19 CAR-T cells BZ019",
    "anti-CD19 CAR T cells BZ019"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd19-targeted-car-t-cells-bz019/"
}