CD19-targeted 4-1BB ligand RO7227166

{
  "id": "MLC-T-ONC-012381",
  "term": "CD19-targeted 4-1BB ligand RO7227166",
  "field": "Oncology and biomedicine",
  "definition": "An immunotherapeutic agent that targets both CD19 and 4-1BB (CDG5:I9necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulatory and antineoplastic activity. Upon administration, CD19-targeted 4-1BB ligand RO7227166 simultaneously binds to CD19 and 4-1BB, thereby crosslinking CD19 and 4-1BB positive cells. This triggers, through the 4-1BB ligand, the proliferation and activation of natural killer cells (NKs) and T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against CD19-expressing tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily (TNFRSF), is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.",
  "synonyms": [
    "CD19-4-1BBL RO7227166"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd19-targeted-4-1bb-ligand-ro7227166/"
}