anti-CEA-CAR autologous T lymphocytes

{
  "id": "MLC-T-ONC-010474",
  "term": "anti-CEA-CAR autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CEA-CAR autologous T-lymphocytes target and bind to tumor cells expressing CEA, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of CEA-expressing tumor cells. CEA is overexpressed in various tumor cell types.",
  "synonyms": [
    "autologous anti-CEA CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cea-car-autologous-t-lymphocytes/"
}