anti-CEA CAR T cells

{
  "id": "MLC-T-ONC-010458",
  "term": "anti-CEA CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CEA CAR T cells specifically recognize and induce selective toxicity in CEA-expressing tumor cells. CEA, a member of the CEA family of proteins, plays a key role in cell migration, cell invasion and cell adhesion, and is overexpressed by a variety of cancer types.",
  "synonyms": [
    "anti-CEA-CAR T lymphocytes",
    "CEA CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cea-car-t-cells/"
}