autologous CEA-specific cytotoxic T-lymphocytes

{
  "id": "MLC-T-ONC-011568",
  "term": "autologous CEA-specific cytotoxic T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated antigen (TAA) human carcinoembryonic antigen (CEA), with potential antineoplastic activity. Dendritic cells (DCs) isolated from the patient’s blood are infected with recombinant adeno-associated virus (AAV) expressing the CEA gene. Exposure of T-lymphocytes to DCs creates CEA-specific CTLs which are expanded. Upon reintroduction of these CTLs into the patient, these cells recognize and kill CEA-expressing tumor cells. CEA, a tumor-associated antigen and a member of the CEA family of proteins, plays a key role in cell migration, cell invasion, and cell adhesion and is overexpressed by a variety of cancer types.",
  "synonyms": [
    "CEA-specific CTLs",
    "CEA-specific AAV-DC-CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cea-specific-cytotoxic-t-lymphocytes/"
}