anti-CEA/anti-CD3 bispecific antibody BA1202

{
  "id": "MLC-T-ONC-010464",
  "term": "anti-CEA/anti-CD3 bispecific antibody BA1202",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CEA/anti-CD3 bispecific antibody BA1202 targets and binds to both CEA expressed on tumor cells and CD3 on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to CEA-expressing tumor cells, which results in the CTL-mediated cell death of CEA-expressing tumor cells. CEA is overexpressed by a variety of cancer cell types and plays a key role in cell migration, cell invasion, and cell adhesion.",
  "synonyms": [
    "anti-CEACAM5/anti-CD3 bispecific antibody BA1202",
    "anti-CEA/CD3 bispecific antibody BA1202",
    "CEA x CD3 bispecific antibody BA1202",
    "anti-CD3/anti-CEA bispecific antibody BA1202"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cea-anti-cd3-bispecific-antibody-ba1202/"
}