anti-CEA/anti-DR5 bispecific antibody IBI3004

{
  "id": "MLC-T-ONC-010466",
  "term": "anti-CEA/anti-DR5 bispecific antibody IBI3004",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and the pro-apoptotic death receptor tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAILR2; death receptor 5; DR5), with potential pro-apoptotic and antineoplastic activities. Upon administration, anti-CEA/anti-DR5 bispecific antibody IBI3004 targets and binds to both CEA and DR5 expressed on tumor cells. Receptor clustering and activation of DR5 induces apoptosis in CEA-expressing tumor cells. Activation of DR5 plays a key role in the induction of apoptosis. CEA-dependent clustering of DR5 allows IBI3004 to selectively induce apoptosis in CEA-expressing tumor cells thereby increasing efficacy and decreasing toxicity. CEA is overexpressed by a variety of cancer cell types and plays a key role in cell migration, cell invasion, and cell adhesion.",
  "synonyms": [
    "anti-CEA/DR5 bispecific antibody IBI3004",
    "anti-DR5/CEA bispecific antibody IBI3004",
    "CEA x DR5 bispecific antibody IBI3004"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cea-anti-dr5-bispecific-antibody-ibi3004/"
}