anti-DR5 agonist monoclonal antibody TRA-8

{
  "id": "MLC-T-ONC-010583",
  "term": "anti-DR5 agonist monoclonal antibody TRA-8",
  "field": "Oncology and biomedicine",
  "definition": "An agonist mouse monoclonal antibody directed against TRAIL death receptor type 5 (DR5) with potential antineoplastic activity. Anti-DR5 agonist monoclonal antibody TRA-8 binds DR5, which may induce apoptosis in DR5-expressing tumor cells. DR5 is a tumor cell surface ligand that crosslinks with death receptor type 4 (DR4) when bound by TRAIL [Tumor necrosis (TNF)-related apoptosis-inducing ligand], triggering apoptosis via a death receptor signaling pathway. The apoptotic activity of this antibody may not require DR4/DR5 crosslinking.",
  "synonyms": [
    "anti-death receptor 5 agonist monoclonal antibody TRA-8"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dr5-agonist-monoclonal-antibody-tra-8/"
}