anti-CEACAM5 antibody-drug conjugate M9140

{
  "id": "MLC-T-ONC-010472",
  "term": "anti-CEACAM5 antibody-drug conjugate M9140",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA), linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-CEACAM5 ADC M9140, the anti-CEACAM5 monoclonal antibody moiety targets and binds to CEACAM5 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills CEACAM5-expressing tumor cells through an as of yet undisclosed mechanism. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "anti-CEA ADC M9140",
    "anti-CEA antibody-drug conjugate M9140",
    "anti-CEACAM5 ADC M9140"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ceacam5-antibody-drug-conjugate-m9140/"
}