anti-CEA TCR retroviral vector-transduced autologous peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-010460",
  "term": "anti-CEA TCR retroviral vector-transduced autologous peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T-cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung , and breast.",
  "synonyms": [
    "anti-CEA TCR retroviral vector-transduced autologous PBLs",
    "anti-CEA TCR-gene engineered autologous lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cea-tcr-retroviral-vector-transduced-autologous-peripheral-blood/"
}