anti-p53 T-cell receptor-transduced peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-010946",
  "term": "anti-p53 T-cell receptor-transduced peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation.",
  "synonyms": [
    "Anti-p53 TCR Retroviral Vector-Transduced PBL",
    "Anti-p53 TCR-Transduced PBL",
    "anti-p53 T-cell receptor retroviral vector-transduced peripheral blood lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-p53-t-cell-receptor-transduced-peripheral-blood-lymphocytes/"
}