anti-K-RAS G12D mTCR-transduced autologous peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-010840",
  "term": "anti-K-RAS G12D mTCR-transduced autologous peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine (Gly, G) to aspartic acid (Asp, D) point mutation at position 12 (G12D) variant of K-RAS (KRAS), with potential immunomodulating and antineoplastic activities. HLA-A1101-positive PBLs are harvested from a K-RAS G12D-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12D mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12D mTCR-expressing PBLs target and bind to K-RAS G12D-overexpressing tumor cells, which results in both cytokine secretion, including interferon-gamma (IFN-g), and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.",
  "synonyms": [
    "anti-KRAS G12D mTCR autologous PBL",
    "anti-K-RAS G12D mTCR-transduced autologous PBLs",
    "anti-KRAS G12D mTCR-transduced autologous peripheral blood lymphocytes",
    "autologous PBL transduced with anti-KRAS G12D mTCR"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-k-ras-g12d-mtcr-transduced-autologous-peripheral-blood-lymphocytes/"
}