anti-K-RAS G12V mTCR-transduced autologous peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-010841",
  "term": "anti-K-RAS G12V mTCR-transduced autologous peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous peripheral blood lymphocytes (PBLs) transduced with an HLA class I histocompatibility antigen A*11:01 (HLA-A1101)-restricted murine T-cell receptor (mTCR) that recognizes the glycine to valine point mutation at position 12 (G12V) variant of K-RAS, with potential antineoplastic activity. HLA-A1101 positive PBLs are harvested from a K-RAS G12V-expressing cancer patient and transfected with a retroviral vector that encodes anti-K-RAS G12V mTCR. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-K-RAS G12V mTCR-expressing PBLs target and bind to K-RAS G12V-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. K-RAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutation of K-RAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.",
  "synonyms": [
    "anti-K-RAS G12V mTCR-transduced autologous PBLs",
    "anti-KRAS G12V mTCR-transduced autologous peripheral blood lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-k-ras-g12v-mtcr-transduced-autologous-peripheral-blood-lymphocytes/"
}