anti-thyroglobulin mTCR-transduced autologous peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-011113",
  "term": "anti-thyroglobulin mTCR-transduced autologous peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Peripheral blood lymphocytes (PBLs) transduced with a gene encoding for a thyroglobulin (TG)-specific murine T-cell receptor (mTCR), with potential antineoplastic activity. PBLs are harvested from a thyroid cancer patient, and transfected with a retroviral vector that encodes the mTCR gene specific for the human TG antigen. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-TG mTCR-expressing PBLs target and bind to TG-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. TG is a thyroid-specific protein.",
  "synonyms": [
    "anti-thyroglobulin mTCR-transduced autologous PBL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-thyroglobulin-mtcr-transduced-autologous-peripheral-blood-lymphocytes/"
}