anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-010762",
  "term": "anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding an anti-Her-2 (epidermal growth factor receptor 2) chimeric T cell receptor (chimeric antigen receptor or CAR) gene with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with Her-2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for Her-2. After expansion in culture and reintroduction into the patient, anti-Her-2-CAR retroviral vector-transduced autologous peripheral blood lymphocytes, expressing anti-Her-2-CAR on their cell surfaces, bind to Her-2 antigen on tumor cell surfaces; subsequently, Her-2-expressing tumor cells may be lysed. Her-2 (ErbB-2), a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the EGFR superfamily and plays key roles in tumor cell proliferation and tumor angiogenesis.",
  "synonyms": [
    "anti-Her-2-chimeric antigen receptor-engineered autologous peripheral blood lymphocytes",
    "anti-Her-2-CAR-engineered autologous PBLs",
    "anti-Her-2-CAR-engineered autologous peripheral blood lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her-2-car-retroviral-vector-transduced-autologous-peripheral-blood/"
}