anti-mesothelin CAR vector-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-010883",
  "term": "anti-mesothelin CAR vector-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Genetically modified, autologous T lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-human tumor-associated antigen (TAA) mesothelin single chain variable fragment (scFv), the intracellular CD3 zeta T-cell receptor domain and the 4-1BB (cd137) costimulatory domain, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the anti-mesothelin CAR vector-transduced autologous T lymphocytes specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-meso-CAR vector-transduced autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mesothelin-car-vector-transduced-autologous-t-lymphocytes/"
}