autologous mesothelin-specific CAR-T cells

{
  "id": "MLC-T-ONC-011696",
  "term": "autologous mesothelin-specific CAR-T cells",
  "field": "Oncology and biomedicine",
  "definition": "Genetically modified, autologous T lymphocytes transduced with a gene encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin, with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture, and reintroduction into the patient, the autologous mesothelin-specific CAR-T cells specifically target and kill mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "Hu-CART meso cells",
    "autologous CART-meso"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mesothelin-specific-car-t-cells/"
}