anti-mesothelin CAR vector-transduced T lymphocytes

{
  "id": "MLC-T-ONC-010884",
  "term": "anti-mesothelin CAR vector-transduced T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified T lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR vector-transduced T-lymphocytes specifically target and kill MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-MSLN CAR-T cells",
    "HuCART-meso"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mesothelin-car-vector-transduced-t-lymphocytes/"
}