anti-MSLN CAR-T cells LCAR-M23

{
  "id": "MLC-T-ONC-010899",
  "term": "anti-MSLN CAR-T cells LCAR-M23",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of Tl ymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR-T cells LCAR-M23 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-mesothelin CAR T cells LCAR-M23",
    "mesothelin-targeting CAR T cells LCAR-M23"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-msln-car-t-cells-lcar-m23/"
}