anti-mesothelin CAR-CD40L-expressing T lymphocytes

{
  "id": "MLC-T-ONC-010885",
  "term": "anti-mesothelin CAR-CD40L-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), and CD40 ligand (CD40L; CD154; TRAP; TNFSF5), with potential immunomodulating and antineoplastic activities. Upon administration, anti-MSLN CAR-CD40L-expressing T lymphocytes specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. CD40L binds to CD40 and activates CD40/CD40L-mediated signaling, which activates monocyte-derived dendritic cells (moDCs), increases the secretion of inflammatory cytokines and further stimulates cytotoxic T lymphocytes (CTLs). This enhances cytotoxicity and anti-tumor immune response.",
  "synonyms": [
    "CD40 ligand expressing MSLN-CAR T cells",
    "anti-MSLN CAR-CD40L-expressing T lymphocytes",
    "anti-MSLN CAR-CD40L-expressing T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mesothelin-car-cd40l-expressing-t-lymphocytes/"
}