anti-mesothelin CIR mRNA-electroporated autologous T cells

{
  "id": "MLC-T-ONC-010886",
  "term": "anti-mesothelin CIR mRNA-electroporated autologous T cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin chimeric T cell receptor mRNA, with potential antineoplastic activity. The anti-mesothelin mRNA encodes a single chain antibody variable fragment (ScFv), the intracellular CD 3 zeta T cell receptor domain and the 4-1BB (cd137) costimulatory domain. Upon intravenous administration, the anti-mesothelin CIR mRNA-electroporated autologous T cells may attach to cancer cells expressing mesothelin. This may stimulate the secretion of multiple cytokines and may result in cell lysis of mesothelin-expressing cancer cells. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers.",
  "synonyms": [
    "autologous redirected RNA meso-CIR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mesothelin-cir-mrna-electroporated-autologous-t-cells/"
}