WT1 mRNA-electroporated autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-017578",
  "term": "WT1 mRNA-electroporated autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1 mRNA-electroporated autologous dendritic cell vaccine may elicit a cytotoxic T-cell (CTL) response against tumor cells expressing WT1. Wt1 is frequently overexpressed in a variety of tumor cell types and often correlates with disease progression and poor prognosis.",
  "synonyms": [
    "Wilms tumor 1 mRNA-electroporated autologous dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/wt1-mrna-electroporated-autologous-dendritic-cell-vaccine/"
}