autologous anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T cells

{
  "id": "MLC-T-ONC-011471",
  "term": "autologous anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-mesothelin M5 single chain variable fragment (scFv) fused to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture and reintroduction into the patient, the autologous anti-mesothelin CAR-CD3zeta-4-1BB-expressing T cells specifically target and induce selective toxicity in mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "Hu-CART-meso cells",
    "mesothelin-specific CAR-T cells",
    "autologous anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mesothelin-car-cd3zeta-4-1-bb-expressing-t-cells/"
}