Autologous anti-mesothelin TCR-expressing T cells FH-TCR TMSLN

{
  "id": "MLC-T-ONC-011477",
  "term": "Autologous anti-mesothelin TCR-expressing T cells FH-TCR TMSLN",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "abbreviation": "FH-TCR TMSLN",
  "synonyms": [
    "autologous mesothelin-specific TCR-expressing T cells FH-TCR TMSLN",
    "autologous mesothelin-specific TCR T cells FH-TCR TMSLN",
    "autologous transgenic T cells expressing mesothelin-specific T-cell receptor FH-TCR TMSLN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mesothelin-tcr-expressing-t-cells-fh-tcr-tmsln/"
}