autologous anti-KK-LC-1 TCR-expressing T cells

{
  "id": "MLC-T-ONC-011463",
  "term": "autologous anti-KK-LC-1 TCR-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) Kita-Kyushu lung cancer antigen-1 (KK-LC-1), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-KK-LC-1 TCR-expressing T cells specifically target and bind to KK-LC-1-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of KK-LC-1-expressing tumor cells. KK-LC-1, a cancer germline (CG) antigen, is expressed in a variety of epithelial cancers and has restricted expression in normal tissues.",
  "synonyms": [
    "Autologous Anti-KK-LC-1 TCR-expressing T-cells",
    "KK-LC-1 TCR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-kk-lc-1-tcr-expressing-t-cells/"
}