TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes

{
  "id": "MLC-T-ONC-017002",
  "term": "TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous T lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers.",
  "abbreviation": "AFP-C332 T cells",
  "synonyms": [
    "AFP-C332 CTLs",
    "anti-AFP TCR-expressing autologous CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tcr-specific-alpha-fetoprotein-enhanced-autologous-t-lymphocytes/"
}