Autologous HBV-specific TCR-expressing T lymphocytes SCG101

{
  "id": "MLC-T-ONC-011641",
  "term": "Autologous HBV-specific TCR-expressing T lymphocytes SCG101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous T lymphocytes transduced with a retroviral vector encoding for a T-cell receptor (TCR) specific for HLA-A*02-restricted human hepatitis B virus (HBV) surface antigen (HBsAg) peptide, with potential antineoplastic activity. Upon administration, the autologous HBV-specific TCR-expressing T lymphocytes SCG101 recognize and bind to HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cells, including those in HBV-related hepatocellular carcinoma (HCC).",
  "synonyms": [
    "autologous HBV-specific T-cell receptor-expressing T lymphocytes SCG101",
    "autologous HBV-specific TCR T cells SCG101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-hbv-specific-tcr-expressing-t-lymphocytes-scg101/"
}