autologous GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes

{
  "id": "MLC-T-ONC-011640",
  "term": "autologous GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD8-positive T lymphocytes that are exposed, ex vivo, to multiple specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetoprotein (AFP), with potential immunostimulating and antineoplastic activities. Upon infusion of the GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes, the T cells specifically target and lyse cells expressing the targeted HCC neoantigens.",
  "synonyms": [
    "autologous specific HCC antigens CD8+ T cells",
    "autologous HCC antigens-specific CD8+ T lymphocytes",
    "autologous HCC antigens-specific CD8-positive T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gpc3-ny-eso-1-afp-specific-cd8-positive-t-lymphocytes/"
}