NY-ESO-1-specific CD4-positive T lymphocytes

{
  "id": "MLC-T-ONC-015574",
  "term": "NY-ESO-1-specific CD4-positive T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4+ T-lymphocytes sensitized to cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. CD4-positive T-lymphocytes are exposed to a NY-ESO-1 peptide ex vivo, expanded, and introduced into the patient. The NY-ESO-1-specific CD4-positive T-lymphocytes may stimulate the host immune system to produce a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, which results in tumor cell lysis. NY-ESO-1, an antigen found in normal testis, may be upregulated in various cancers.",
  "synonyms": [
    "CD4+ NY-ESO-1-specific T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ny-eso-1-specific-cd4-positive-t-lymphocytes/"
}