autologous NY-ESO-1 TCR-targeted T lymphocytes

{
  "id": "MLC-T-ONC-011723",
  "term": "autologous NY-ESO-1 TCR-targeted T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human autologous T lymphocytes that are transduced with a gene encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR-transduced autologous T cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells.",
  "synonyms": [
    "NY-ESO-1 T Cell receptor genetically modified autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-ny-eso-1-tcr-targeted-t-lymphocytes/"
}