autologous NSCLC peptide-specific dendritic cell vaccine

{
  "id": "MLC-T-ONC-011722",
  "term": "autologous NSCLC peptide-specific dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A personalized cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with immunogenic peptides derived from autologous non-small cell lung cancer (NSCLC) cells, with potential immunostimulating and antineoplastic activities. During leukapheresis, mature DCs are loaded with autologous NSCLC-derived peptides. Upon re-administration of the NSCLC peptide-specific DC vaccine, the immune system is exposed to NSCLC-associated antigens. This results in the induction of a specific cytotoxic T-lymphocyte (CTL) response against NSCLC cells and tumor cell lysis.",
  "synonyms": [
    "autologous NSCLC peptide-specific DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-nsclc-peptide-specific-dendritic-cell-vaccine/"
}