autologous tumor-associated peptide antigen-pulsed dendritic cell vaccine

{
  "id": "MLC-T-ONC-011801",
  "term": "autologous tumor-associated peptide antigen-pulsed dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with specific tumor-associated peptide antigens (TAPA), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous TAPA-pulsed DC vaccine exposes the immune system to the specific TAPAs, which may result in cytotoxic T-lymphocyte (CTL)-mediated immune responses against the TAPA-expressing cancer cells. This leads to cancer cell lysis. This vaccine is specific towards peptides derived from the following proteins: sperm autoantigenic protein 17 (SP17), ropporin, A-kinase anchor protein 4 (AKAP4), pituitary tumor-transforming 1 (PTTG1) and SPANX family member B (SPANX-B).",
  "abbreviation": "autologous TAPA-pulsed DC vaccine KiroVAX",
  "synonyms": [
    "KiroVAX",
    "autologous TAPA loaded DC vaccine",
    "autologous tumor-associated peptide antigen-pulsed DC vaccine KiroVAX"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tumor-associated-peptide-antigen-pulsed-dendritic-cell-vaccine/"
}