autologous colorectal tumor antigen-pulsed dendritic cell vaccine

{
  "id": "MLC-T-ONC-011580",
  "term": "autologous colorectal tumor antigen-pulsed dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with tumor cell lysates from a colorectal cancer patient containing tumor-associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous colorectal tumor antigen-pulsed DC vaccine exposes the immune system to colorectal tumor cell antigens, which may result in cytotoxic T-lymphocyte (CTL)-mediated immune responses against the colorectal cancer cells. This leads to cancer cell lysis. The tumor cell lysate contains a range of antigens that are essential for the neoplastic growth and survival of the cancer cells.",
  "synonyms": [
    "APDC vaccine",
    "autologous colorectal tumor antigen-pulsed DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-colorectal-tumor-antigen-pulsed-dendritic-cell-vaccine/"
}