Autologous CRISPR-Cas9 engineered regnase-1/SOCS1 dual-edited tumor infiltrating lymphocytes KSQ-004EX

{
  "id": "MLC-T-ONC-011581",
  "term": "Autologous CRISPR-Cas9 engineered regnase-1/SOCS1 dual-edited tumor infiltrating lymphocytes KSQ-004EX",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to inactivate both the endogenous genes suppressor of cytokine signaling 1 (SOCS1) and Regnase-1, with potential immunomodulating and antineoplastic activities. Upon infusion of the autologous CRISPR-Cas9 engineered Regnase-1/SOCS1 dual-edited TILs KSQ-004EX back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. Inactivation of endogenous SOCS1 and Regnase-1 in the TILs increases responsiveness to cytokine signals, increases persistence and memory formation of TILs, and enhances anti-tumor responses.",
  "synonyms": [
    "autologous CRISPR-Cas9 engineered TILs KSQ-004EX",
    "autologous dual-edit eTILs KSQ-004EX",
    "autologous engineered tumor infiltrating lymphocytes KSQ-004EX",
    "autologous eTILs KSQ-004EX",
    "autologous SOCS1/regnase-1 inactivated engineered TILs KSQ-004EX",
    "autologous SOCS1/Regnase-1-edited TILs KSQ-004EX",
    "CRISPR/Cas9-edited SOCS1/Regnase-1 gene-inactivated autologous TILs KSQ-004EX",
    "Regnase-1/SOCS1 dual-edited human CRISPR/Cas9-engineered TILs KSQ-004EX"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-crispr-cas9-engineered-regnase-1-socs1-dual-edited-tumor-infiltrating/"
}