autologous CRISPR-edited tumor infiltrating lymphocytes GT316

{
  "id": "MLC-T-ONC-011586",
  "term": "autologous CRISPR-edited tumor infiltrating lymphocytes GT316",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from each patient's resected tumor and edited with the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to eliminate the expression of as of yet not elucidated immunoregulatory targets, with potential immunomodulating and antineoplastic activities. Upon administration back into the patient, autologous CRISPR-edited TILs GT316 specifically recognize and kill the patient's tumor cells. The knockout of the immunoregulatory targets may enhance the proliferation and cytokine release of the TILs.",
  "synonyms": [
    "autologous CRISPR-edited TILs GT316",
    "autologous TILs GT316",
    "autologous tumor infiltrating lymphocytes GT316",
    "CRISPR/Cas9-engineered TILs GT316"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-crispr-edited-tumor-infiltrating-lymphocytes-gt316/"
}