autologous CRISPR-Cas9 engineered tumor infiltrating lymphocytes KSQ-001EX

{
  "id": "MLC-T-ONC-011582",
  "term": "autologous CRISPR-Cas9 engineered tumor infiltrating lymphocytes KSQ-001EX",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to inactivate the endogenous gene suppressor of cytokine signaling 1 (SOCS1), with potential immunomodulating and antineoplastic activities. Upon infusion of the autologous CRISPR-Cas9 engineered TILs KSQ-001EX back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. SOCS1 serves as a negative regulator of cytokine signaling in T cells and negatively influences the survival, differentiation, and function of T cells. Inactivation of endogenous SOCS1 in TILs increases responsiveness to cytokine signals, and enhances anti-tumor potency, persistence and memory formation of TILs.",
  "synonyms": [
    "autologous CRISPR-Cas9 engineered TILs KSQ-001EX",
    "autologous engineered tumor infiltrating lymphocytes KSQ-001EX",
    "autologous eTILs KSQ-001EX",
    "autologous SOCS1 inactivated engineered TILs KSQ-001EX",
    "autologous SOCS1-edited TILs KSQ-001EX",
    "CRISPR/Cas9-edited SOCS1 gene-inactivated autologous TILs KSQ-001EX"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-crispr-cas9-engineered-tumor-infiltrating-lymphocytes-ksq-001ex/"
}