allogeneic CRISPR-Cas9-engineered anti-CD70 CAR-T cells CTX130

{
  "id": "MLC-T-ONC-009867",
  "term": "allogeneic CRISPR-Cas9-engineered anti-CD70 CAR-T cells CTX130",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human allogeneic T lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR-T cells CTX130 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR-T cells.",
  "synonyms": [
    "allogeneic CRISPR-Cas9-engineered T cells CTX130",
    "CRISPR/Cas9 gene-edited allogeneic anti-CD70 CAR-T cells CTX130",
    "donor-derived gene-edited allogeneic CAR-T cells CTX130"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-crispr-cas9-engineered-anti-cd70-car-t-cells-ctx130/"
}