Allogeneic mesothelioma tumor lysate-pulsed autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-009919",
  "term": "Allogeneic mesothelioma tumor lysate-pulsed autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with a mixture of lysates from five allogeneic mesothelioma tumor cell lines, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, DCs are loaded with allogeneic mesothelioma tumor cell lysates. Upon re-administration of the allogeneic mesothelioma tumor lysate-pulsed autologous DC vaccine, the immune system is exposed to an undefined amount of mesothelioma-associated antigens, which stimulates the induction of a specific cytotoxic T-lymphocyte (CTL) response against mesothelioma tumor cells and leads to tumor cell lysis.",
  "synonyms": [
    "MesoCancerVac",
    "allogeneic mesothelioma tumor lysate-pulsed autologous DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-mesothelioma-tumor-lysate-pulsed-autologous-dendritic-cell-vaccine/"
}