allogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-009920",
  "term": "allogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor.",
  "synonyms": [
    "most closely HLA-matched third-party donor adenovirus-specific T cells",
    "most closely HLA-matched third-party donor adenovirus Specific CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-most-closely-hla-matched-adenovirus-specific-cytotoxic-t-lymphocytes/"
}