allogeneic adenovirus-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-009789",
  "term": "allogeneic adenovirus-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of allogeneic cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene.",
  "synonyms": [
    "allogeneic adenovirus-specific CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-adenovirus-specific-cytotoxic-t-lymphocytes/"
}