allogeneic CMV/AdV-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-009863",
  "term": "allogeneic CMV/AdV-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV) and adenovirus (AdV) with potential antiviral activity. Allogeneic CMV/AdV-specific cytotoxic T lymphocytes are prepared by exposing donor-derived CTLs to a lethally irradiated Epstein-Barr virus-positive lymphoblastoid B cell line (EBV-LCL) that has been transduced with a clinical-grade adenoviral vector (Ad5f35CMVpp65) as a source of CMV and AdV antigens. Infusion of these CTLs into stem cell transplant recipients may prevent CMV and AdV viral disease.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cmv-adv-specific-cytotoxic-t-lymphocytes/"
}