Posoleucel

{
  "id": "MLC-T-ONC-016189",
  "term": "Posoleucel",
  "field": "Oncology and biomedicine",
  "definition": "A population of closely human leukocyte antigen (HLA)-matched, off-the-shelf (OTS), donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards six viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6; HHV-6), human polyomavirus type I (BKV) and human polyomavirus type II (JC virus; JCV), with potential antiviral activity. Upon infusion into allogeneic hematopoietic stem cell transplant (HSCT) recipients and immunocompromised patients, posoleucel provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. This may prevent EBV, CMV, AdV, HHV6, BKV and JCV reactivation and infection, and inhibits viral-associated diseases.",
  "synonyms": [
    "allogeneic EBV/CMV/AdV/HHV6/BKV/JCV-specific CTLs ALVR105",
    "allogeneic multi-virus-specific CTLs ALVR105",
    "allogeneic multi-virus-specific cytotoxic T lymphocytes ALVR105",
    "VSTs ALVR105"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/posoleucel/"
}