partially HLA-matched AdV/CMV/EBV-specific allogeneic T lymphocytes

{
  "id": "MLC-T-ONC-015855",
  "term": "partially HLA-matched AdV/CMV/EBV-specific allogeneic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Partially or closely human leukocyte antigen (HLA)-matched allogeneic cytotoxic T lymphocytes (CTLs), derived from cell lines, specifically reactive to the three human viruses adenovirus (AdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV-specific allogeneic T lymphocytes in immunocompromised patients or upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, and/or EBV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens.",
  "synonyms": [
    "partially HLA-matched adenovirus/cytomegalovirus/Epstein-Barr virus-specific allogeneic cytotoxic T lymphocytes",
    "partially HLA-matched AdV/CMV/EBV-specific allogeneic T cells",
    "allogeneic HLA-matched VSTs",
    "allogeneic partially HLA-matched AdV/CMV/EBV-specific T cells",
    "allogeneic HLA-matched virus-specific T cell lines"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/partially-hla-matched-adv-cmv-ebv-specific-allogeneic-t-lymphocytes/"
}