partially engineered T-regulatory cell donor graft TRGFT-201

{
  "id": "MLC-T-ONC-015854",
  "term": "partially engineered T-regulatory cell donor graft TRGFT-201",
  "field": "Oncology and biomedicine",
  "definition": "A T-regulatory (Treg) cell donor graft that has been partially engineered by depleting all the T cells and then enriching the graft with infusions of conventional T-cells, Tregs and CD34+ stem cells derived from peripheral blood from either related or unrelated matched donors, with potential immunomodulating activity. Upon administration of the partially engineered T-regulatory cell donor graft TRGFT-201 following myeloablation, the allograft may induce tolerance in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT) as treatment for hematologic malignancies.",
  "synonyms": [
    "partially engineered and enriched Treg donor graft TRGFT-201",
    "T-cell-depleted graft with additional infusion of conventional T cells and regulatory T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/partially-engineered-t-regulatory-cell-donor-graft-trgft-201/"
}