CD3+/CD19+ cell-depleted unrelated or partially matched donor-derived allogeneic peripheral blood stem cells

{
  "id": "MLC-T-ONC-012403",
  "term": "CD3+/CD19+ cell-depleted unrelated or partially matched donor-derived allogeneic peripheral blood stem cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of CD3-positive (CD3+) T cells and CD19-positive (CD19+) B cells via leukapheresis with potential immune reconstituting activity. The CD3+/CD19+ cell-depleted PBSCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD) and Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders.",
  "synonyms": [
    "CD3+ and CD19+ cell-depleted allogeneic PBSCs derived from an unrelated or partially matched donor",
    "CD3+/CD19+ cell-depleted unrelated or partially matched donor-derived allogeneic PBSCs",
    "CD3+ T-cell-depleted/CD19+ B-cell-depleted unrelated or partially matched donor-derived allogeneic peripheral blood stem cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd3-plus-cd19-plus-cell-depleted-unrelated-or-partially-matched-donor-derived/"
}