CD3+/CD19+ cell-depleted autologous hematopoietic stem cells

{
  "id": "MLC-T-ONC-012402",
  "term": "CD3+/CD19+ cell-depleted autologous hematopoietic stem cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively depleted of CD3-positive (CD3+) T cells and CD19-positive (CD19+) B cells, with potential immune reconstituting activity. Upon administration, the CD3+/CD19+ cell-depleted autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow for rapid and sustained engraftment and immune reconstitution without the autoreactive CD3+ T cells and CD19+ B cells. This may alleviate manifestations of autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis.",
  "synonyms": [
    "autologous CD3+/CD19+ cell-depleted HSCs",
    "CD3+/CD19+ cell-depleted autologous HSCs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd3-plus-cd19-plus-cell-depleted-autologous-hematopoietic-stem-cells/"
}