TCR alpha/beta/CD19-depleted allogeneic hematopoietic progenitor cells

{
  "id": "MLC-T-ONC-017000",
  "term": "TCR alpha/beta/CD19-depleted allogeneic hematopoietic progenitor cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of hematopoietic progenitor cells (HPCs) from a haploidentical donor that have been depleted of T-cell receptor (TCR) alpha and beta (TCRa/b+) as well as CD19-positive (CD19+) cells, that can potentially be used for immune reconstitution purposes. The TCR alpha/beta/CD19-depleted HPCs contain high amounts of natural killer (NK) cells, gamma/delta T cells, CD34+ stem cells, monocytes, and dendritic cells (DCs), while devoid of alpha/beta T cells and CD19-positive B cells. The TCR alpha/beta/CD19-depleted HPCs are used for allogeneic hematopoietic cell transplantation (HCT) and may allow for rapid and sustained engraftment, rapid immune reconstitution, and may prevent or reduce graft-versus-host disease (GvHD).",
  "synonyms": [
    "TCR alpha/beta/CD19-depleted HPCs",
    "TCR alpha/beta+/CD19+ depleted ematopoietic progenitor cells",
    "TCR alpha/beta+/CD19+ depleted HPCs",
    "TCRab+/CD19+-depleted haploidentical donor HPCs",
    "TCRab-/CD19-depleted hematopoietic progenitor cells",
    "TCRab-/CD19-depleted allogeneic hematopoietic progenitor cells",
    "allogeneic alpha, beta TCR/CD19-depleted HPCs",
    "allogeneic TCRab/CD19-depleted hematopoietic stem cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tcr-alpha-beta-cd19-depleted-allogeneic-hematopoietic-progenitor-cells/"
}